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Switch #:
SWTI000048
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T286 in the Pin1-binding motif of G1/S-specific cyclin-D1 (Ccnd1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein.

Participants:
(1) G1/S-specific cyclin-D1 (Ccnd1)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interactions
Interaction #1 Ccnd1 - Pin1

Interfaces
(1) DOC_WW_Pin1_4 motif (283LACTPT288) in G1/S-specific cyclin-D1 (Ccnd1)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T286 on G1/S-specific cyclin-D1 (Ccnd1)) of the G1/S-specific cyclin-D1 (Ccnd1) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) WW domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: T286 : Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Dyrk1b), Glycogen synthase kinase-3 beta (Gsk3b), Glycogen synthase kinase-3 beta (GSK3B).

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes.
Liou et al. Proc. Natl. Acad. Sci. U.S.A. (2002)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) - 28 more (view)
G1/S-specific cyclin-D1 (Ccnd1) - 1 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)


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