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Switch #:
SWTI000055
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S203 in the Pin1-binding motif of Steroidogenic factor 1 (Nr5a1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein.

Participants:
(1) Steroidogenic factor 1 (Nr5a1)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interactions
Interaction #1 Nr5a1 - Pin1

Interfaces
(1) DOC_WW_Pin1_4 motif (200PYASPP205) in Steroidogenic factor 1 (Nr5a1)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S203 on Steroidogenic factor 1 (Nr5a1)) of the Steroidogenic factor 1 (Nr5a1) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) WW domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S203 : Cyclin-dependent kinase 7 (CDK7), Mitogen-activated protein kinase 3 (Mapk3), Mitogen-activated protein kinase 1 (Mapk1), Mitogen-activated protein kinase 1 (MAPK1).

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) Pin1 facilitates the phosphorylation-dependent ubiquitination of SF-1 to regulate gonadotropin beta-subunit gene transcription.
Luo et al. Mol. Cell. Biol. (2010)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) - 28 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)


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