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Switch #:
SWTI000056
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S246 in the Pin1-binding motif of Catenin beta-1 (CTNNB1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Catenin beta-1 (CTNNB1)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 CTNNB1 - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (243MLGSPV248) in Catenin beta-1 (CTNNB1)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S246 on Catenin beta-1 (CTNNB1)) of the Catenin beta-1 (CTNNB1) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S246 : Cyclin-dependent kinase 5 (CDK5).

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC.
Ryo et al. Nat. Cell Biol. (2001)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)
Catenin beta-1 (CTNNB1) - 3 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)


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