Interaction #1 CTNNB1 - PIN1
(1) DOC_WW_Pin1_4 motif (243MLGSPV248) in Catenin beta-1 (CTNNB1)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)
PTM-dependent Induction (Phosphorylation of S246 on Catenin beta-1 (CTNNB1)) of the Catenin beta-1 (CTNNB1) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction
Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S246 : Cyclin-dependent kinase 5 (CDK5).
(1) Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC.
Other switches involving participants