Switch #: SWTI000062

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S2121 in the Pin1-binding motif of Neurogenic locus notch homolog protein 1 (NOTCH1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Neurogenic locus notch homolog protein 1 (NOTCH1)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

(1) The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer.
Rustighi et al. Nat. Cell Biol. (2009)

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)
Neurogenic locus notch homolog protein 1 (NOTCH1) - 3 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)