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Switch #:
SWTI000063
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T2132 in the Pin1-binding motif of Neurogenic locus notch homolog protein 1 (NOTCH1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Neurogenic locus notch homolog protein 1 (NOTCH1)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Context
References

(1) The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer.
Rustighi et al. Nat. Cell Biol. (2009)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)
Neurogenic locus notch homolog protein 1 (NOTCH1) - 3 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)




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