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Switch #:
SWTI000074
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S910 in the Pin1-binding motif of Focal adhesion kinase 1 (PTK2) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Focal adhesion kinase 1 (PTK2)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 PTK2 - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (907QEISPP912) in Focal adhesion kinase 1 (PTK2)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S910 on Focal adhesion kinase 1 (PTK2)) of the Focal adhesion kinase 1 (PTK2) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S910 : Cyclin-dependent kinase 5 (CDK5).

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST.
Zheng et al. Mol. Cell (2009)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)
Focal adhesion kinase 1 (PTK2) - 3 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)


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