About Help Definitions Submit Search Analyse Browse Home


Switch #:
SWTI000073
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T254 in the Pin1-binding motif of Transcription factor p65 (RELA) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Transcription factor p65 (RELA)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 RELA - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (251VFRTPP256) in Transcription factor p65 (RELA)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T254 on Transcription factor p65 (RELA)) of the Transcription factor p65 (RELA) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Context
References

(1) Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.
Ryo et al. Mol. Cell (2003)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) - 55 more (view)
Transcription factor p65 (RELA) - 1 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)




Loading visualisation

           
Please send any suggestions/comments to: switches@elm.eu.org