Switch #: SWTI000076

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S136 in the Pin1-binding motif of CREB-regulated transcription coactivator 2 (Crtc2) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein.

Participants:
(1) CREB-regulated transcription coactivator 2 (Crtc2)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

(1) Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity.
Nakatsu et al. J. Biol. Chem. (2010)

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) - 28 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)