Switch #: SWTI000077

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S385 in the Pin1-binding motif of G1/S-specific cyclin-E1 (Ccne1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein.

Participants:
(1) G1/S-specific cyclin-E1 (Ccne1)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

(1) The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability.
Yeh et al. J. Biol. Chem. (2006)

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) - 28 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)