Switch #: SWTI000078

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S52 in the Pin1-binding motif of Homeobox protein NANOG (Nanog) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein.

Participants:
(1) Homeobox protein NANOG (Nanog)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

(1) Phosphorylation stabilizes Nanog by promoting its interaction with Pin1.
Moretto-Zita et al. Proc. Natl. Acad. Sci. U.S.A. (2010)

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) - 28 more (view)
Homeobox protein NANOG (Nanog) - 1 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)