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Switch #:
SWTI000082
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S188 in the Pin1-binding motif of Gephyrin (Gphn) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein.

Participants:
(1) Gephyrin (Gphn)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interactions
Interaction #1 Gphn - Pin1

Interfaces
(1) DOC_WW_Pin1_4 motif (185DLPSPP190) in Gephyrin (Gphn)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S188 on Gephyrin (Gphn)) of the Gephyrin (Gphn) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) WW domain interaction

Context
References

(1) Post-phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function.
Zita et al. EMBO J. (2007)

See also

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) - 28 more (view)
Gephyrin (Gphn) - 2 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)




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