Switch #: SWTI000083

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S194 in the Pin1-binding motif of Gephyrin (Gphn) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein.

Participants:
(1) Gephyrin (Gphn)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

(1) Post-phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function.
Zita et al. EMBO J. (2007)

Other switches involving participants
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) - 28 more (view)
Gephyrin (Gphn) - 2 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)