Switches.ELM

Switch #:

SWTI000113

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S428 by in the 14-3-3-binding motif of cGMP-inhibited 3',5'-cyclic phosphodiesterase A (PDE3A) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein.

Participants:
(1) cGMP-inhibited 3',5'-cyclic phosphodiesterase A (PDE3A)
(2) 14-3-3 protein zeta/delta (YWHAZ)

Interactions

Interaction #1 PDE3A - YWHAZ

Interfaces
(1) LIG_14-3-3_2 motif (₄₂₄RLRRSLP₄₃₀) in cGMP-inhibited 3',5'-cyclic phosphodiesterase A (PDE3A)
(2) 14-3-3 protein_(3-236) in 14-3-3 protein zeta/delta (YWHAZ)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S₄₂₈ on cGMP-inhibited 3',5'-cyclic phosphodiesterase A (PDE3A)) of the cGMP-inhibited 3',5'-cyclic phosphodiesterase A (PDE3A) LIG_14-3-3_2 motif - 14-3-3 protein zeta/delta (YWHAZ) 14-3-3 protein interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S₄₂₈: PKC subfamily

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S₄₂₈ : Protein kinase C alpha type (PRKCA).

Context

References

(1) Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428.
Pozuelo Rubio et al. Biochem. J. (2005)