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Switch #:
SWTI000117
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S1263 in the BRCT-binding motif of Acetyl-CoA carboxylase 1 (ACACA) induces binding to the Breast cancer type 1 susceptibility protein (BRCA1) protein.

Participants:
(1) Acetyl-CoA carboxylase 1 (ACACA)
(2) Breast cancer type 1 susceptibility protein (BRCA1)

Interactions
Interaction #1 ACACA - BRCA1

Interfaces
(1) LIG_BRCT_BRCA1_1 motif (1262QSPTF1266) in Acetyl-CoA carboxylase 1 (ACACA)
(2) BRCA1 C Terminus (BRCT) domain (1648-1723) and (1756-1842) in Breast cancer type 1 susceptibility protein (BRCA1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S1263 on Acetyl-CoA carboxylase 1 (ACACA)) of the Acetyl-CoA carboxylase 1 (ACACA) LIG_BRCT_BRCA1_1 motif - Breast cancer type 1 susceptibility protein (BRCA1) BRCA1 C Terminus (BRCT) domain interaction

Context
References

(1) ACCA phosphopeptide recognition by the BRCT repeats of BRCA1.
Ray et al. J. Mol. Biol. (2006)

See also

Other switches involving participants
Breast cancer type 1 susceptibility protein (BRCA1) - 6 more (view)

Other switches involving interfaces
LIG_BRCT_BRCA1_1 - 4 more (view)
BRCA1 C Terminus (BRCT) domain - 6 more (view)




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