Switch #: SWTI000118

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S406 in the BRCT-binding motif of BRCA1-A complex subunit Abraxas (FAM175A) induces binding to the Breast cancer type 1 susceptibility protein (BRCA1) protein.

Participants:
(1) BRCA1-A complex subunit Abraxas (FAM175A)
(2) Breast cancer type 1 susceptibility protein (BRCA1)

(1) Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.
Wang et al. Science (2007)

Other switches involving participants
Breast cancer type 1 susceptibility protein (BRCA1) - 6 more (view)

Other switches involving interfaces
LIG_BRCT_BRCA1_1 - 4 more (view)
BRCA1 C Terminus (BRCT) domain - 6 more (view)