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Switch #:
SWTI000119
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S239 in the BRCT-binding motif of ATR-interacting protein (ATRIP) induces binding to the Breast cancer type 1 susceptibility protein (BRCA1) protein.

Participants:
(1) ATR-interacting protein (ATRIP)
(2) Breast cancer type 1 susceptibility protein (BRCA1)

Interactions
Interaction #1 ATRIP - BRCA1

Interfaces
(1) LIG_BRCT_BRCA1_1 motif (238CSPQF242) in ATR-interacting protein (ATRIP)
(2) BRCA1 C Terminus (BRCT) domain (1648-1723) and (1756-1842) in Breast cancer type 1 susceptibility protein (BRCA1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S239 on ATR-interacting protein (ATRIP)) of the ATR-interacting protein (ATRIP) LIG_BRCT_BRCA1_1 motif - Breast cancer type 1 susceptibility protein (BRCA1) BRCA1 C Terminus (BRCT) domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S239 : Cyclin-dependent kinase 2 (CDK2).

Context
Switch localisation
ELM curated: nucleus, BRCA1-BARD1 complex
Inferred: nucleoplasm


Switch pathways
Inferred: Fanconi anemia pathway
References

(1) Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function.
Venere et al. Cancer Res. (2007)

See also

Other switches involving participants
Breast cancer type 1 susceptibility protein (BRCA1) - 6 more (view)

Other switches involving interfaces
LIG_BRCT_BRCA1_1 - 4 more (view)
BRCA1 C Terminus (BRCT) domain - 6 more (view)


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