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Physicochemical compatibility

Phosphorylation of T603 in the FHA-binding motif of DNA repair protein RAD9 (RAD9) induces binding to the Serine/threonine-protein kinase RAD53 (RAD53) protein.

(1) DNA repair protein RAD9 (RAD9)
(2) Serine/threonine-protein kinase RAD53 (RAD53)

Interaction #1 RAD9 - RAD53

(1) LIG_FHA_1 motif (601ELTQELP607) in DNA repair protein RAD9 (RAD9)
(2) FHA domain (601-681) in Serine/threonine-protein kinase RAD53 (RAD53)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T603 on DNA repair protein RAD9 (RAD9)) of the DNA repair protein RAD9 (RAD9) LIG_FHA_1 motif - Serine/threonine-protein kinase RAD53 (RAD53) FHA domain interaction

Additional Information
Affinity : 12.9 µM
Structural information: 1K2N

(1) Solution structure of the yeast Rad53 FHA2 complexed with a phosphothreonine peptide pTXXL: comparison with the structures of FHA2-pYXL and FHA1-pTXXD complexes.
Byeon et al. J. Mol. Biol. (2001)

See also

Other switches involving participants
Serine/threonine-protein kinase RAD53 (RAD53) - 3 more (view)
DNA repair protein RAD9 (RAD9) - 2 more (view)

Other switches involving interfaces
LIG_FHA_1 - 5 more (view)
FHA domain - 11 more (view)

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