Switches.ELM

Switch #:

SWTI000130

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T523 in the FHA-binding motif of DNA repair protein XRCC1 (XRCC1) by Casein kinase II subunit alpha (CSNK2A1) induces binding to the Aprataxin (APTX) protein.

Participants:
(1) DNA repair protein XRCC1 (XRCC1)
(2) Aprataxin (APTX)

Interactions

Interaction #1 XRCC1 - APTX

Interfaces
(1) LIG_FHA_2 motif (₅₂₁ENTDSEE₅₂₇) in DNA repair protein XRCC1 (XRCC1)
(2) FHA domain_(25-116) in Aprataxin (APTX)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T₅₂₃ on DNA repair protein XRCC1 (XRCC1)) of the DNA repair protein XRCC1 (XRCC1) LIG_FHA_2 motif - Aprataxin (APTX) FHA domain interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: T₅₂₃: Casein kinase II subunit alpha (CSNK2A1)

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: T₅₂₃ : Casein kinase II subunit alpha' (CSNK2A2), Casein kinase II subunit alpha (CSNK2A1).

Context

References

(1) A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment.
Luo et al. Mol. Cell. Biol. (2004)