Switches.ELM

Switch #:

SWTI000131

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T233 in the FHA-binding motif of DNA repair protein XRCC4 (XRCC4) by Casein kinase II subunit alpha (CSNK2A1) induces binding to the Bifunctional polynucleotide phosphatase/kinase (PNKP) protein.

Participants:
(1) DNA repair protein XRCC4 (XRCC4)
(2) Bifunctional polynucleotide phosphatase/kinase (PNKP)

Interactions

Interaction #1 XRCC4 - PNKP

Interfaces
(1) LIG_FHA_2 motif (₂₃₁ESTDEES₂₃₇) in DNA repair protein XRCC4 (XRCC4)
(2) Bifunctional polynucleotide phosphatase/kinase (PNKP)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T₂₃₃ on DNA repair protein XRCC4 (XRCC4)) of the DNA repair protein XRCC4 (XRCC4) LIG_FHA_2 motif - Bifunctional polynucleotide phosphatase/kinase (PNKP) interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: T₂₃₃: Casein kinase II subunit alpha (CSNK2A1)

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: T₂₃₃ : Casein kinase II subunit alpha (CSNK2A1).

Context

References

(1) Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.
Koch et al. EMBO J. (2004)