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Switch #:
SWTI000141
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1596 in the PTB-binding motif of Integrin beta-4 (ITGB4) induces binding to the SHC-transforming protein 1 (SHC1) protein.

Participants:
(1) Integrin beta-4 (ITGB4)
(2) SHC-transforming protein 1 (SHC1)

Interactions
Interaction #1 ITGB4 - SHC1

Interfaces
(1) LIG_PTB_Phospho_1 motif (1590LLPNHSY1596) in Integrin beta-4 (ITGB4)
(2) Phosphotyrosine interaction domain (PTB/PID) (162-318) in SHC-transforming protein 1 (SHC1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1596 on Integrin beta-4 (ITGB4)) of the Integrin beta-4 (ITGB4) LIG_PTB_Phospho_1 motif - SHC-transforming protein 1 (SHC1) Phosphotyrosine interaction domain (PTB/PID) interaction

Context
Switch localisation
ELM curated: integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex


Switch pathways
Inferred: Focal adhesion
References

(1) Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes.
Dans et al. J. Biol. Chem. (2001)

See also

Other switches involving participants
SHC-transforming protein 1 (SHC1) - 15 more (view)

Other switches involving interfaces
LIG_PTB_Phospho_1 - 18 more (view)
Phosphotyrosine interaction domain (PTB/PID) - 14 more (view)


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