Interaction #1 ITGB4 - SHC1
(1) LIG_PTB_Phospho_1 motif (1590LLPNHSY1596) in Integrin beta-4 (ITGB4)
(2) Phosphotyrosine interaction domain (PTB/PID) (162-318) in SHC-transforming protein 1 (SHC1)
PTM-dependent Induction (Phosphorylation of Y1596 on Integrin beta-4 (ITGB4)) of the Integrin beta-4 (ITGB4) LIG_PTB_Phospho_1 motif - SHC-transforming protein 1 (SHC1) Phosphotyrosine interaction domain (PTB/PID) interaction
ELM curated: integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex
(1) Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes.
Other switches involving participants