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Switch #:
SWTI000142
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y4507 in the PTB-binding motif of Prolow-density lipoprotein receptor-related protein 1 (LRP1) induces binding to the SHC-transforming protein 1 (SHC1) protein.

Participants:
(1) Prolow-density lipoprotein receptor-related protein 1 (LRP1)
(2) SHC-transforming protein 1 (SHC1)

Interactions
Interaction #1 LRP1 - SHC1

Interfaces
(1) LIG_PTB_Phospho_1 motif (4501NFTNPVY4507) in Prolow-density lipoprotein receptor-related protein 1 (LRP1)
(2) Phosphotyrosine interaction domain (PTB/PID) (162-318) in SHC-transforming protein 1 (SHC1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y4507 on Prolow-density lipoprotein receptor-related protein 1 (LRP1)) of the Prolow-density lipoprotein receptor-related protein 1 (LRP1) LIG_PTB_Phospho_1 motif - SHC-transforming protein 1 (SHC1) Phosphotyrosine interaction domain (PTB/PID) interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y4507 : Proto-oncogene tyrosine-protein kinase Src (SRC).

Context
Switch localisation
ELM curated: integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex
Inferred: nucleus
References

(1) v-Src induces Shc binding to tyrosine 63 in the cytoplasmic domain of the LDL receptor-related protein 1.
Barnes et al. Oncogene (2003)

See also

Other switches involving participants
SHC-transforming protein 1 (SHC1) - 15 more (view)

Other switches involving interfaces
LIG_PTB_Phospho_1 - 18 more (view)
Phosphotyrosine interaction domain (PTB/PID) - 14 more (view)


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