Switches.ELM

Switch #:

SWTI000144

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y553 in the PTB-binding motif of Muscle, skeletal receptor tyrosine-protein kinase (Musk) induces binding to the Protein Dok-7 (Dok7) protein.

Participants:
(1) Muscle, skeletal receptor tyrosine-protein kinase (Musk)
(2) Protein Dok-7 (Dok7)

Interactions

Interaction #1 Musk - Dok7

Interfaces
(1) LIG_PTB_Phospho_1 motif (₅₄₇LHPNPMY₅₅₃) in Muscle, skeletal receptor tyrosine-protein kinase (Musk)
(2) PTB domain (IRS-1 type)_(110-204) in Protein Dok-7 (Dok7)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y₅₅₃ on Muscle, skeletal receptor tyrosine-protein kinase (Musk)) of the Muscle, skeletal receptor tyrosine-protein kinase (Musk) LIG_PTB_Phospho_1 motif - Protein Dok-7 (Dok7) PTB domain (IRS-1 type) interaction

Additional Information
Structural information: 3ML4

Context

References

(1) The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization.
Bergamin et al. Mol. Cell (2010)