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Switch #:
SWTI000145
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y496 in the PTB-binding motif of High affinity nerve growth factor receptor (NTRK1) induces binding to the SHC-transforming protein 1 (SHC1) protein.

Participants:
(1) High affinity nerve growth factor receptor (NTRK1)
(2) SHC-transforming protein 1 (SHC1)

Interactions
Interaction #1 NTRK1 - SHC1

Interfaces
(1) LIG_PTB_Phospho_1 motif (490IIENPQY496) in High affinity nerve growth factor receptor (NTRK1)
(2) Phosphotyrosine interaction domain (PTB/PID) (162-318) in SHC-transforming protein 1 (SHC1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y496 on High affinity nerve growth factor receptor (NTRK1)) of the High affinity nerve growth factor receptor (NTRK1) LIG_PTB_Phospho_1 motif - SHC-transforming protein 1 (SHC1) Phosphotyrosine interaction domain (PTB/PID) interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y496 : High affinity nerve growth factor receptor (NTRK1).

Additional Information
Structural information: 1SHC
Context
Switch localisation
ELM curated: integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex


Switch pathways
Inferred: Neurotrophin signaling pathway
References

(1) Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
Zhou et al. Nature (1995)

See also

Other switches involving participants
SHC-transforming protein 1 (SHC1) - 15 more (view)
High affinity nerve growth factor receptor (NTRK1) - 2 more (view)

Other switches involving interfaces
LIG_PTB_Phospho_1 - 18 more (view)
Phosphotyrosine interaction domain (PTB/PID) - 14 more (view)


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