About Help Definitions Submit Search Analyse Browse Home


Switch #:
SWTI000146
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1063 in the PTB-binding motif of Proto-oncogene tyrosine-protein kinase receptor Ret (Ret) induces binding to the Docking protein 1 (Dok1) protein.

Participants:
(1) Proto-oncogene tyrosine-protein kinase receptor Ret (Ret)
(2) Docking protein 1 (Dok1)

Interactions
Interaction #1 Ret - Dok1

Interfaces
(1) LIG_PTB_Phospho_1 motif (1057WIENKLY1063) in Proto-oncogene tyrosine-protein kinase receptor Ret (Ret)
(2) PTB domain (IRS-1 type) (151-254) in Docking protein 1 (Dok1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1063 on Proto-oncogene tyrosine-protein kinase receptor Ret (Ret)) of the Proto-oncogene tyrosine-protein kinase receptor Ret (Ret) LIG_PTB_Phospho_1 motif - Docking protein 1 (Dok1) PTB domain (IRS-1 type) interaction


Additional Information
Structural information: 1UEF
Context
References

(1) Structural basis for the specific recognition of RET by the Dok1 phosphotyrosine binding domain.
Shi et al. J. Biol. Chem. (2004)

See also

Other switches involving interfaces
LIG_PTB_Phospho_1 - 18 more (view)
PTB domain (IRS-1 type) - 12 more (view)




Loading visualisation

           
Please send any suggestions/comments to: switches@elm.eu.org