Switch #: SWTI000147

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y1022 in the PTB-binding motif of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) induces binding to the SHC-transforming protein 1 (SHC1) protein.

Participants:
(1) Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D)
(2) SHC-transforming protein 1 (SHC1)

(1) The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis.
Liu et al. J. Biol. Chem. (1997)

(2) Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIP.
Lamkin et al. J. Biol. Chem. (1997)

Other switches involving participants
SHC-transforming protein 1 (SHC1) - 15 more (view)
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) - 4 more (view)

Other switches involving interfaces
LIG_PTB_Phospho_1 - 18 more (view)
Phosphotyrosine interaction domain (PTB/PID) - 14 more (view)