Switch #: SWTI000149

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S422 by Serine/threonine-protein kinase mTOR (MTOR) (as part of mTORC2 complex) in the PIF pocket-binding motif of Serine/threonine-protein kinase Sgk1 (SGK1) induces intramolecular binding and kinase cis-activation.

Participants:
(1) Serine/threonine-protein kinase Sgk1 (SGK1)

(1) The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.
Biondi et al. EMBO J. (2001)

(2) mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).
García-Martínez et al. Biochem. J. (2008)

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DOC_AGCK_PIF_1 - 9 more (view)
Protein kinase domain - 35 more (view)