Switch #: SWTI000150

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of T737 by Serine/threonine-protein kinase TOR1 (TOR1) in the PIF pocket-binding motif of Serine/threonine-protein kinase SCH9 (SCH9) induces intramolecular binding and kinase cis-activation.

Participants:
(1) Serine/threonine-protein kinase SCH9 (SCH9)

(1) Yeast 3-phosphoinositide-dependent protein kinase-1 (PDK1) orthologs Pkh1-3 differentially regulate phosphorylation of protein kinase A (PKA) and the protein kinase B (PKB)/S6K ortholog Sch9.
Voordeckers et al. J. Biol. Chem. (2011)

(2) Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.
Urban et al. Mol. Cell (2007)

Other switches involving interfaces
DOC_AGCK_PIF_1 - 9 more (view)
Protein kinase domain - 35 more (view)