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Switch #:
SWTI000151
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Auto-phosphorylation of S386 in the PIF pocket-binding motif of Ribosomal protein S6 kinase alpha-3 (Rps6ka3) induces intramolecular binding and kinase cis-activation.

Participants:
(1) Ribosomal protein S6 kinase alpha-3 (Rps6ka3)

Interactions
Context
References

(1) A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.
Frödin et al. EMBO J. (2000)

See also

Other switches involving interfaces
DOC_AGCK_PIF_1 - 9 more (view)
Protein kinase domain - 35 more (view)




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