Switches.ELM

Switch #:

SWTI000152

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S474 in the PIF pocket-binding motif of RAC-beta serine/threonine-protein kinase (AKT2) induces intramolecular binding and kinase cis-activation.

Participants:
(1) RAC-beta serine/threonine-protein kinase (AKT2)

Interactions

Interaction #1 AKT2 - AKT2(intramolecular)
intramolecular
Interfaces
(1) DOC_AGCK_PIF_1 motif (₄₇₀FPQFSY₄₇₅) in RAC-beta serine/threonine-protein kinase (AKT2)
(2) Protein kinase domain_(152-409) in RAC-beta serine/threonine-protein kinase (AKT2)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S₄₇₄ on RAC-beta serine/threonine-protein kinase (AKT2)) of the RAC-beta serine/threonine-protein kinase (AKT2) DOC_AGCK_PIF_1 motif - RAC-beta serine/threonine-protein kinase (AKT2) Protein kinase domain interaction

Additional Information
Structural information: 1O6L

Context

References

(1) Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP.
Yang et al. Nat. Struct. Biol. (2002)