Switches.ELM

Switch #:

SWTI000153

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T412 in the PIF pocket-binding motif of Ribosomal protein S6 kinase beta-1 (Rps6kb1) induces intramolecular binding and kinase cis-activation.

Participants:
(1) Ribosomal protein S6 kinase beta-1 (Rps6kb1)

Interactions

Interaction #1 Rps6kb1 - Rps6kb1(intramolecular)
intramolecular
Interfaces
(1) DOC_AGCK_PIF_1 motif (₄₀₈FLGFTY₄₁₃) in Ribosomal protein S6 kinase beta-1 (Rps6kb1)
(2) Protein kinase domain_(91-352) in Ribosomal protein S6 kinase beta-1 (Rps6kb1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T₄₁₂ on Ribosomal protein S6 kinase beta-1 (Rps6kb1)) of the Ribosomal protein S6 kinase beta-1 (Rps6kb1) DOC_AGCK_PIF_1 motif - Ribosomal protein S6 kinase beta-1 (Rps6kb1) Protein kinase domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: T₄₁₂ : Serine/threonine-protein kinase Nek6 (NEK6), 3-phosphoinositide-dependent protein kinase 1 (Pdpk1), Serine/threonine-protein kinase mTOR (MTOR).

Context

References

(1) The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.
Biondi et al. EMBO J. (2001)