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Switch #:
SWTI000155
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S486 in the PIF pocket-binding motif of Serine/threonine-protein kinase Sgk3 (SGK3) induces intramolecular binding and kinase cis-activation.

Participants:
(1) Serine/threonine-protein kinase Sgk3 (SGK3)

Interactions
Interaction #1 SGK3 - SGK3(intramolecular)
intramolecular
Interfaces
(1) DOC_AGCK_PIF_1 motif (482FVGFSY487) in Serine/threonine-protein kinase Sgk3 (SGK3)
(2) Protein kinase domain (162-419) in Serine/threonine-protein kinase Sgk3 (SGK3)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S486 on Serine/threonine-protein kinase Sgk3 (SGK3)) of the Serine/threonine-protein kinase Sgk3 (SGK3) DOC_AGCK_PIF_1 motif - Serine/threonine-protein kinase Sgk3 (SGK3) Protein kinase domain interaction

Context
Switch localisation
ELM curated: cytosol, internal side of plasma membrane
References

(1) Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3.
Tessier et al. J. Biol. Chem. (2006)

See also

Other switches involving interfaces
DOC_AGCK_PIF_1 - 9 more (view)
Protein kinase domain - 35 more (view)


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