Switch #: SWTI000156

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S486 in the PIF pocket-binding motif of Serine/threonine-protein kinase Sgk3 (Sgk3) induces intramolecular binding and kinase cis-activation.

Participants:
(1) Serine/threonine-protein kinase Sgk3 (Sgk3)

(1) Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner.
Nilsen et al. J. Biol. Chem. (2004)

Other switches involving interfaces
DOC_AGCK_PIF_1 - 9 more (view)
Protein kinase domain - 35 more (view)