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Physicochemical compatibility

Dual phosphorylation of S157 and S161 in the TrCP1-binding motif of NF-kappa-B inhibitor epsilon (NFKBIE) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

(1) NF-kappa-B inhibitor epsilon (NFKBIE)
(2) F-box/WD repeat-containing protein 1A (BTRC)

Interaction #1 NFKBIE - BTRC

(1) DEG_SCF_TRCP1_1 motif (156DSGIES161) in NF-kappa-B inhibitor epsilon (NFKBIE)
(2) WD domain, G-beta repeat (297-329) and (333-369) and (373-409) and (416-452) and (456-492) and (496-532) and (545-581) in F-box/WD repeat-containing protein 1A (BTRC)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S157 and S161 on NF-kappa-B inhibitor epsilon (NFKBIE)) of the NF-kappa-B inhibitor epsilon (NFKBIE) DEG_SCF_TRCP1_1 motif - F-box/WD repeat-containing protein 1A (BTRC) WD domain, G-beta repeat interaction


(1) Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1.
Shirane et al. J. Biol. Chem. (1999)

(2) I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
Whiteside et al. EMBO J. (1997)

See also

Other switches involving participants
F-box/WD repeat-containing protein 1A (BTRC) - 17 more (view)

Other switches involving interfaces
WD domain, G-beta repeat - 36 more (view)
DEG_SCF_TRCP1_1 - 17 more (view)

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