Interaction #1 FBXO5 - BTRC
(1) DEG_SCF_TRCP1_1 motif (144DSGYSS149) in F-box only protein 5 (FBXO5)
(2) WD domain, G-beta repeat (297-329) and (333-369) and (373-409) and (416-452) and (456-492) and (496-532) and (545-581) in F-box/WD repeat-containing protein 1A (BTRC)
PTM-dependent Induction (Phosphorylation of S145 and S149 on F-box only protein 5 (FBXO5)) of the F-box only protein 5 (FBXO5) DEG_SCF_TRCP1_1 motif - F-box/WD repeat-containing protein 1A (BTRC) WD domain, G-beta repeat interaction
Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S145 : Serine/threonine-protein kinase PLK1 (PLK1). S149 : Serine/threonine-protein kinase PLK1 (PLK1).
ELM curated: nucleoplasm, nucleus, Chromosome, cytosol
Switch cell cycle phase
Curated: Oocyte meiosis, SCF-beta-TrCP mediated degradation of Emi1
(1) Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo.
Other switches involving participants