Switches.ELM

Switch #:

SWTI000169

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Dual phosphorylation of S145 and S149 in the TrCP1-binding motif of F-box only protein 5 (FBXO5) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

Participants:
(1) F-box only protein 5 (FBXO5)
(2) F-box/WD repeat-containing protein 1A (BTRC)

Interactions

Interaction #1 FBXO5 - BTRC

Interfaces
(1) DEG_SCF_TRCP1_1 motif (₁₄₄DSGYSS₁₄₉) in F-box only protein 5 (FBXO5)
(2) WD domain, G-beta repeat_(297-329) and _(333-369) and _(373-409) and _(416-452) and _(456-492) and _(496-532) and _(545-581) in F-box/WD repeat-containing protein 1A (BTRC)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S₁₄₅ and S₁₄₉ on F-box only protein 5 (FBXO5)) of the F-box only protein 5 (FBXO5) DEG_SCF_TRCP1_1 motif - F-box/WD repeat-containing protein 1A (BTRC) WD domain, G-beta repeat interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S₁₄₅ : Serine/threonine-protein kinase PLK1 (PLK1). S₁₄₉ : Serine/threonine-protein kinase PLK1 (PLK1).

Context

Switch localisation
Curated: cytosol
ELM curated: nucleoplasm, nucleus, Chromosome, cytosol

Inferred: cytosol

Switch cell cycle phase
Curated: prophase

Switch pathways
Curated: Oocyte meiosis, SCF-beta-TrCP mediated degradation of Emi1

References

(1) Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo.
Guardavaccaro et al. Dev. Cell (2003)