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Switch #:
SWTI000171
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S10 in the Pin1-binding motif of F-box only protein 5-A (fbxo5-a) induces binding to the pin1 protein.

Participants:
(1) F-box only protein 5-A (fbxo5-a)
(2) pin1

Interactions
Interaction #1 fbxo5-a - pin1

Interfaces
(1) DOC_WW_Pin1_4 motif (7SNQSPK12) in F-box only protein 5-A (fbxo5-a)
(2) WW domain (7-37) in pin1

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S10 on F-box only protein 5-A (fbxo5-a)) of the F-box only protein 5-A (fbxo5-a) DOC_WW_Pin1_4 motif - pin1 WW domain interaction

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) Pin1 stabilizes Emi1 during G2 phase by preventing its association with SCF(betatrcp).
Bernis et al. EMBO Rep. (2007)

See also

Other switches involving participants
pin1 - 1 more (view)

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)


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