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Switch #:
SWTI000172
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S654 in the Pin1-binding motif of Protein SPT23 (SPT23) induces binding to the Peptidyl-prolyl cis-trans isomerase ESS1 (ESS1) protein.

Participants:
(1) Protein SPT23 (SPT23)
(2) Peptidyl-prolyl cis-trans isomerase ESS1 (ESS1)

Interactions
Interaction #1 SPT23 - ESS1

Interfaces
(1) DOC_WW_Pin1_4 motif (651SDSSPS656) in Protein SPT23 (SPT23)
(2) WW domain (11-41) in Peptidyl-prolyl cis-trans isomerase ESS1 (ESS1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S654 on Protein SPT23 (SPT23)) of the Protein SPT23 (SPT23) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase ESS1 (ESS1) WW domain interaction

Context
Switch localisation
ELM curated: nucleus, cytosol
Inferred: nucleus
References

(1) Prolyl isomerase Pin1 acts as a switch to control the degree of substrate ubiquitylation.
Siepe et al. Nat. Cell Biol. (2009)

See also

Other switches involving interfaces
DOC_WW_Pin1_4 - 90 more (view)
WW domain - 105 more (view)


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