Switch #: SWTI000179

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y281 in the ITSM motif of Signaling lymphocytic activation molecule (SLAMF1) induces binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via one of its SH2 domains.

Participants:
(1) Signaling lymphocytic activation molecule (SLAMF1)
(2) Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)

(1) CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A.
Shlapatska et al. J. Immunol. (2001)

Other switches involving participants
Signaling lymphocytic activation molecule (SLAMF1) - 3 more (view)
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) - 9 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_TYR_ITSM - 4 more (view)