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Switch #:
SWTI000180
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y327 in the ITSM motif of Signaling lymphocytic activation molecule (SLAMF1) induces binding of Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) via one of its SH2 domains.

Participants:
(1) Signaling lymphocytic activation molecule (SLAMF1)
(2) Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)

Interactions
Interaction #1 SLAMF1 - PTPN11

Interfaces
(1) LIG_TYR_ITSM motif (323SITVYASV330) in Signaling lymphocytic activation molecule (SLAMF1)
(2) SH2 domain (6-81) and (112-197) in Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y327 on Signaling lymphocytic activation molecule (SLAMF1)) of the Signaling lymphocytic activation molecule (SLAMF1) LIG_TYR_ITSM motif - Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y327 : Tyrosine-protein kinase Fyn (FYN), Tyrosine-protein kinase Lyn (LYN).

Context
Switch localisation
Curated: cytoplasmic side of plasma membrane
ELM curated: cytosol
References

(1) CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A.
Shlapatska et al. J. Immunol. (2001)

See also

Other switches involving participants
Signaling lymphocytic activation molecule (SLAMF1) - 3 more (view)
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) - 9 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_TYR_ITSM - 4 more (view)


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