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Switch #:
SWTI000181
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y895 in the SH2-binding motif of Insulin receptor substrate 1 (Irs1) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.

Participants:
(1) Insulin receptor substrate 1 (Irs1)
(2) Growth factor receptor-bound protein 2 (Grb2)

Interactions
Interaction #1 Irs1 - Grb2

Interfaces
(1) LIG_SH2_GRB2 motif (895YVNI898) in Insulin receptor substrate 1 (Irs1)
(2) SH2 domain (60-135) in Growth factor receptor-bound protein 2 (Grb2)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y895 on Insulin receptor substrate 1 (Irs1)) of the Insulin receptor substrate 1 (Irs1) LIG_SH2_GRB2 motif - Growth factor receptor-bound protein 2 (Grb2) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y895 : Insulin-like growth factor 1 receptor (IGF1R), Tyrosine-protein kinase Fyn (Fyn), Insulin receptor (Insr), Insulin receptor (INSR).

Context
Switch localisation
ELM curated: cytosol
Inferred: cytosol, nucleus


Switch pathways
Inferred: PI3K-Akt signaling pathway, Neurotrophin signaling pathway, Insulin signaling pathway
References

(1) Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.
Sun et al. Mol. Cell. Biol. (1993)

See also

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_SH2_GRB2 - 6 more (view)


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