Switch #: SWTI000190

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of S321 in the 14-3-3-binding motif of M-phase inducer phosphatase 2 (CDC25B) by Cyclin-dependent kinase 1 (CDK1) during mitosis abolishes binding of the motif, phosphorylated at S323, to 14-3-3 protein beta/alpha (YWHAB), thereby maintaining active Cdc25B.

Participants:
(1) M-phase inducer phosphatase 2 (CDC25B)
(2) 14-3-3 protein beta/alpha (YWHAB)

(1) Mitotic phosphorylation of Cdc25B Ser321 disrupts 14-3-3 binding to the high affinity Ser323 site.
Astuti et al. J. Biol. Chem. (2010)

Other switches involving participants
M-phase inducer phosphatase 2 (CDC25B) - 2 more (view)
14-3-3 protein beta/alpha (YWHAB) - 8 more (view)

Other switches involving interfaces
LIG_14-3-3_3 - 16 more (view)
14-3-3 protein - 38 more (view)