Description: Phosphorylation of T779 in the PTB-binding motif of Integrin beta-3 (ITGB3) inhibits its interaction with SHC-transforming protein 1 (SHC1).
Participants: (1) Integrin beta-3 (ITGB3) (2) SHC-transforming protein 1 (SHC1)
(1) Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding.Kirk et al. J. Biol. Chem. (2000) (2) Integrin {beta}3 phosphorylation dictates its complex with the Shc phosphotyrosine-binding (PTB) domain.Deshmukh et al. J. Biol. Chem. (2010)
Other switches involving participantsSHC-transforming protein 1 (SHC1) - 15 more (view)Integrin beta-3 (ITGB3) - 15 more (view)Other switches involving interfacesLIG_PTB_Phospho_1 - 18 more (view)Phosphotyrosine interaction domain (PTB/PID) - 14 more (view)
Your browser does not support iframes.