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Switch #:
SWTI000202
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T779 in the PTB-binding motif of Integrin beta-3 (ITGB3) inhibits its interaction with SHC-transforming protein 1 (SHC1).

Participants:
(1) Integrin beta-3 (ITGB3)
(2) SHC-transforming protein 1 (SHC1)

Interactions
Interaction #1 ITGB3 - SHC1

Interfaces
(1) LIG_PTB_Phospho_1 motif (779TFTNITY785) in Integrin beta-3 (ITGB3)
(2) Phosphotyrosine interaction domain (PTB/PID) (162-318) in SHC-transforming protein 1 (SHC1)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of T779 on Integrin beta-3 (ITGB3)) of the Integrin beta-3 (ITGB3) LIG_PTB_Phospho_1 motif - SHC-transforming protein 1 (SHC1) Phosphotyrosine interaction domain (PTB/PID) interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: T779 : 3-phosphoinositide-dependent protein kinase 1 (PDPK1).

Additional Information
Structural information: 2L1C
Context
Switch localisation
ELM curated: integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex


Switch pathways
Inferred: Focal adhesion
References

(1) Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding.
Kirk et al. J. Biol. Chem. (2000)

(2) Integrin {beta}3 phosphorylation dictates its complex with the Shc phosphotyrosine-binding (PTB) domain.
Deshmukh et al. J. Biol. Chem. (2010)

See also

Other switches involving participants
SHC-transforming protein 1 (SHC1) - 15 more (view)
Integrin beta-3 (ITGB3) - 15 more (view)

Other switches involving interfaces
LIG_PTB_Phospho_1 - 18 more (view)
Phosphotyrosine interaction domain (PTB/PID) - 14 more (view)


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