Interaction #1 ITGB3 - SHC1
(1) LIG_PTB_Phospho_1 motif (779TFTNITY785) in Integrin beta-3 (ITGB3)
(2) Phosphotyrosine interaction domain (PTB/PID) (162-318) in SHC-transforming protein 1 (SHC1)
PTM-dependent Abrogation (Phosphorylation of T779 on Integrin beta-3 (ITGB3)) of the Integrin beta-3 (ITGB3) LIG_PTB_Phospho_1 motif - SHC-transforming protein 1 (SHC1) Phosphotyrosine interaction domain (PTB/PID) interaction
Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: T779 : 3-phosphoinositide-dependent protein kinase 1 (PDPK1).
Structural information: 2L1C
ELM curated: integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex
(1) Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding.
Other switches involving participants