Switch #: SWTI000201

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of T743 adjacent to the PTB-binding motif of Amyloid beta A4 protein (APP) reduces the affinity for Amyloid beta A4 precursor protein-binding family B member 1 (APBB1).

Participants:
(1) Amyloid beta A4 protein (APP)
(2) Amyloid beta A4 precursor protein-binding family B member 1 (APBB1)

(1) Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2.
Radzimanowski et al. EMBO Rep. (2008)

Other switches involving participants
Amyloid beta A4 protein (APP) - 2 more (view)
Amyloid beta A4 precursor protein-binding family B member 1 (APBB1) - 1 more (view)

Other switches involving interfaces
Phosphotyrosine interaction domain (PTB/PID) - 14 more (view)
LIG_PTB_Apo_2 - 3 more (view)