Interaction #1 APP - APBB1
(1) LIG_PTB_Apo_2 motif (756GYENPTYK763) in Amyloid beta A4 protein (APP)
(2) Phosphotyrosine interaction domain (PTB/PID) (543-664) in Amyloid beta A4 precursor protein-binding family B member 1 (APBB1)
PTM-dependent Abrogation (Phosphorylation of T743 on Amyloid beta A4 protein (APP)) of the Amyloid beta A4 protein (APP) LIG_PTB_Apo_2 motif - Amyloid beta A4 precursor protein-binding family B member 1 (APBB1) Phosphotyrosine interaction domain (PTB/PID) interaction
Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: T743 : Glycogen synthase kinase-3 beta (GSK3B), Cyclin-dependent kinase 1 (CDK1).
Affinity : T743: 0.22 µM, pT743: 1.56 µM
Structural information: 3DXC, 3DXD, 3DXE
ELM curated: integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex
(1) Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2.
Other switches involving participants