Switch #: SWTI000227

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Asialoglycoprotein receptor 1 (ASGR1) via an endocytosis motif.

Participants:
(1) Asialoglycoprotein receptor 1 (ASGR1)
(2) AP-2 complex subunit mu (AP2M1)

(1) Endocytosis of the ASGP receptor H1 is reduced by mutation of tyrosine-5 but still occurs via coated pits.
Fuhrer et al. J. Cell Biol. (1991)

(2) Related signals for endocytosis and basolateral sorting of the asialoglycoprotein receptor.
Geffen et al. J. Biol. Chem. (1993)

Other switches involving participants
AP-2 complex subunit mu (AP2M1) - 15 more (view)

Other switches involving interfaces
TRG_ENDOCYTIC_2 - 21 more (view)
Adaptor complexes medium subunit family - 21 more (view)