Switch #: SWTI000228

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Lysosome-associated membrane glycoprotein 1 (LAMP1) via an endocytosis motif.

Participants:
(1) Lysosome-associated membrane glycoprotein 1 (LAMP1)
(2) AP-2 complex subunit mu (AP2M1)

(1) The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targetting to lysosomes.
Obermüller et al. J. Cell. Sci. (2002)

(2) Accumulation of membrane glycoproteins in lysosomes requires a tyrosine residue at a particular position in the cytoplasmic tail.
Williams et al. J. Cell Biol. (1990)

(3) Cytoplasmic determinants involved in direct lysosomal sorting, endocytosis, and basolateral targeting of rat lgp120 (lamp-I) in MDCK cells.
Höning et al. J. Cell Biol. (1995)

Other switches involving participants
AP-2 complex subunit mu (AP2M1) - 15 more (view)

Other switches involving interfaces
TRG_ENDOCYTIC_2 - 21 more (view)
Adaptor complexes medium subunit family - 21 more (view)