Switch #: SWTI000229

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Cytotoxic T-lymphocyte protein 4 (CTLA4) via an endocytosis motif.

Participants:
(1) Cytotoxic T-lymphocyte protein 4 (CTLA4)
(2) AP-2 complex subunit mu (AP2M1)

(1) Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2.
Shiratori et al. Immunity (1997)

Other switches involving participants
AP-2 complex subunit mu (AP2M1) - 15 more (view)

Other switches involving interfaces
TRG_ENDOCYTIC_2 - 21 more (view)
Adaptor complexes medium subunit family - 21 more (view)