Switch #: SWTI000230

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Neural cell adhesion molecule L1 (L1CAM) via an endocytosis motif.

Participants:
(1) Neural cell adhesion molecule L1 (L1CAM)
(2) AP-2 complex subunit mu (AP2M1)

(1) Characterization of the neuron-specific L1-CAM cytoplasmic tail: naturally disordered in solution it exercises different binding modes for different adaptor proteins.
Tyukhtenko et al. Biochemistry (2008)

Other switches involving participants
AP-2 complex subunit mu (AP2M1) - 15 more (view)
Neural cell adhesion molecule L1 (L1CAM) - 3 more (view)

Other switches involving interfaces
TRG_ENDOCYTIC_2 - 21 more (view)
Adaptor complexes medium subunit family - 21 more (view)