Switch #: SWTI000231

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Envelope glycoprotein (env) via an endocytosis motif.

Participants:
(1) Envelope glycoprotein (env)
(2) AP-2 complex subunit mu (AP2M1)

(1) Dileucine and YXXL motifs in the cytoplasmic tail of the bovine leukemia virus transmembrane envelope protein affect protein expression on the cell surface.
Novakovic et al. J. Virol. (2004)

Other switches involving participants
Envelope glycoprotein (env) - 1 more (view)

Other switches involving interfaces
TRG_ENDOCYTIC_2 - 21 more (view)
Adaptor complexes medium subunit family - 21 more (view)