Switch #: SWTI000233

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Niemann-Pick C1 protein (NPC1) via an endocytosis motif.

Participants:
(1) Niemann-Pick C1 protein (NPC1)
(2) AP-2 complex subunit sigma (AP2S1)

(1) Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization.
Watari et al. Proc. Natl. Acad. Sci. U.S.A. (1999)

Other switches involving participants
AP-2 complex subunit sigma (AP2S1) - 11 more (view)

Other switches involving interfaces
TRG_LysEnd_APsAcLL_1 - 14 more (view)
Clathrin adaptor complex small chain - 15 more (view)