Switch #: SWTI000234

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of HLA class II histocompatibility antigen gamma chain (CD74) via an endocytosis motif.

Participants:
(1) HLA class II histocompatibility antigen gamma chain (CD74)
(2) AP-2 complex subunit sigma (AP2S1)

(1) Structure-activity relationship of the leucine-based sorting motifs in the cytosolic tail of the major histocompatibility complex-associated invariant chain.
Motta et al. J. Biol. Chem. (1995)

(2) A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway.
Pond et al. J. Biol. Chem. (1995)

Other switches involving participants
AP-2 complex subunit sigma (AP2S1) - 11 more (view)
HLA class II histocompatibility antigen gamma chain (CD74) - 1 more (view)

Other switches involving interfaces
TRG_LysEnd_APsAcLL_1 - 14 more (view)
Clathrin adaptor complex small chain - 15 more (view)