Switch #: SWTI000235

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (Ap2s1) subunit for recruitment of T-cell surface glycoprotein CD3 delta chain (Cd3d) via an endocytosis motif.

Participants:
(1) T-cell surface glycoprotein CD3 delta chain (Cd3d)
(2) AP-2 complex subunit sigma (Ap2s1)

(1) A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains.
Letourneur et al. Cell (1992)

Other switches involving participants
AP-2 complex subunit sigma (Ap2s1) - 2 more (view)

Other switches involving interfaces
TRG_LysEnd_APsAcLL_1 - 14 more (view)
Clathrin adaptor complex small chain - 15 more (view)